Publications

Our Publications

LivTME Cancer Research Team

RESEARCH & RECENT KEY FINDINGS

Dr Michael Schmid, joint research leader, in this video, describes the need for research and publications. He highlights the need for better therapies for pancreatic cancer patients in addition to the prognosis pancreatic cancer patients have, meaning, from a hundred patients diagnosed only some seven patients actually survive more than five years.

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Publications to-date

  • Yuliana Astuti, Meirion Raymant, Valeria Quaranta, Kim Clarke, Maidinaimu Abudula, Olivia Smith, Gaia Bellomo, Vatshala Chandran-Gorner, Craig Nourse, Christopher Halloran, Paula Ghaneh, Daniel Palmer, Robert P. Jones, Fiona Campbell, Jeffrey W. Pollard, Jennifer P. Morton, Ainhoa Mielgo, Michael C. Schmid. Efferocytosis reprograms the tumour microenvironment and promotes pancreatic cancer liver metastasis. Nature Cancer, 2024. DOI: 10.1038/s43018-024-00731-2
  • Raymant M., Astuti Y., Alvaro-Espinosa L., Green D., Quaranta V, Bellomo V., Glenn M., Chandran-Gorner V., Palmer D., Halloran C., Ghaneh P., Henderson N., Morton J., Valiente M, Mielgo A, Schmid MC. Macrophage-fibroblast JAK/STAT dependent crosstalk promotes liver metastatic outgrowth in pancreatic cancer. Nature Communications, 2024. DOI: 10.1038/s41467-024-47949-3
  • Teifion Luckett, Abudula Maidinaimu, Lucy Ireland, Mark Glenn, Gaia Bellomo, Ruth Stafferton, Chris Halloran, Paula Ghaneh, Rob Jones, Michael C. Schmid, Ainhoa Mielgo. Mesothelin secretion by pancreatic cancer cells co-opts macrophages and promotes metastasis. Cancer Research, 2024. DOI: 10.1158/0008-5472.CAN-23-1542
  • Patrick Freeman, Gaia Bellomo, Lucy Ireland, Maidinaimu Abudula, Teifion Luckett, Michael Oberst, Ruth Stafferton, Paula Ghaneh, Chris Halloran, Michael C Schmid, Ainhoa Mielgo. Inhibition of insulin-like growth factors increases production of CXCL9/10 by macrophages and fibroblasts and facilitates CD8+ cytotoxic T cell recruitment to pancreatic tumours. Frontiers in Immunology, 2024. DOI: 10.3389/fimmu.2024.1382538
  • Tanakamol Mahawan, Teifion Luckett, Ainhoa Mielgo, Natapol Pornputtapong, Eva Caamaño Gutiérrez. Robust and consistent biomarker candidates identification by a machine learning approach applied to pancreatic ductal adenocarcinoma metastasis. BMC Med Inform Decis Mak, 2024. DOI: 10.1186/s12911-024-02578-0
  • Sufyan Elhashani, Mark Glenn, Meirion Raymant, Michael C Schmid, Ainhoa Mielgo. Expression of versican isoforms V0/V1 by pancreatic cancer associated fibroblasts increases fibroblast proliferation. Pancreatology, 2024. DOI: 10.1016/j.pan.2024.04.008
  • Robert P Jones, Ainhoa Mielgo, Michael Schmid, Danielle Bury, Timothy Andrews, Susanne Burdak-Rothkamm, Michael Shackcloth, Timothy J. S. Cross, Stephen Fenwick, Hassan Z Malik, Rafa Diaz-Nieto, Christian Ottensmeier, Daniel H Palmer, Dale Vimalachandran. PINCER (A Platform Study for solId orgaN CancERs): an agile pan-network platform study to deliver high-quality translational Research. British Journal of Surgery, 2023. DOI: 10.1093/bjs/znad097
  • Gaia Bellomo, Carolyn Rainer, Valeria Quaranta, Yuliana Astuti, Meirion Raymant, Elzbieta Boyd, Ruth Stafferton, Fiona Campbell, Dean E Hammond, Jennifer P Morton, Daniel Palmer, Dale Vimalachandran, Robert Jones, Ainhoa Mielgo & Michael C Schmid. Chemotherapy-induced infiltration of neutrophils promotes pancreatic cancer metastasis via Gas6/AXL signalling axis. Gut, 2022. DOI: 10.1136/gutjnl-2021-325272
  • Lucy Ireland, Teifion Luckett, Michael C. Schmid, Ainhoa Mielgo. Blockade of stromal Gas6 alters cancer cell plasticity, activates NK cells and inhibits pancreatic cancer metastasis. Frontiers in Immunology, 2020. DOI: 10.3389/fimmu.2020.00297
  • Patrick Freeman and Ainhoa Mielgo. Cancer-Associated Fibroblast Mediated Inhibition of CD8+ Cytotoxic T Cell Accumulation in Tumours: Mechanisms and Therapeutic Opportunities. Cancers, 2020. DOI: 10.3390/cancers12092687
  • Ainhoa Mielgo and Michael C. Schmid. Liver Tropism in Cancer: The Hepatic Metastatic Niche. Cold Spring Harb Perspect Med, 2020. DOI: 10.1101/cshperspect.a037259
  • Schmid MC, Khan SQ, Kaneda MM, Pathria P, Shepard R, Louis TL, Anand S, Woo G, Leem C, Faridi MH, Geraghty T, Rajagopalan A, Gupta S, Ahmed M, Vazquez-Padron RI, Cheresh DA, Gupta V, Varner JA. Integrin CD11b activation drives anti-tumor innate immunity. Nature Communications, 2018. DOI: 10.1038/s41467-018-07387-4
  • Lucy Ireland and Ainhoa Mielgo. Macrophages and Fibroblasts, Key Players in Cancer Chemoresistance. Frontiers in Cell & Dev. Biology, 2018. DOI: 10.3389/fcell.2018.00131
  • Tanton H, Voronina S, Evans A, Armstrong J, Sutton R, Criddle DN, Haynes L, Schmid MC, Campbell F, Costello E and Tepikin AV. F1F0-ATP Synthase Inhibitory Factor 1 in the Normal Pancreas and in Pancreatic Ductal Adenocarcinoma: Effects on Bioenergetics, Invasion and Proliferation. Front. Physiol., 2018. DOI: 10.3389/fphys.2018.00833
  • Carlos R Figueiredo, Ricardo A Azevedo, Sasha Mousdell, Pedro T Resende-Lara, Lucy Ireland, Almudena Santos, Natalia Girola, Rodrigo L.O.R Cunha, Michael Schmid, Luciano Polonelli, Luiz R. Travassos, Ainhoa Mielgo. Interfering with MIF-CD74 signalling on macrophages and dendritic cells with a peptide-based approach restores the immune response against metastatic melanoma. Frontiers in Immunology, 2018. DOI: 10.3389/fimmu.2018.01132
  • Valeria Quaranta, Carolyn Rainer, Sebastian R Nielsen, Meirion Raymant, Muhammad S Ahmed, Dannielle Engle, Arthur Taylor, Trish Murray, Fiona Campbell, Daniel Palmer, David Tuveson, Ainhoa Mielgo, Michael Schmid. Macrophage-derived granulin drives resistance to immune checkpoint inhibition in metastatic pancreatic cancer. Cancer Research, 2018. DOI: 10.1158/0008-5472.CAN-17-3876
  • Lucy Ireland, Almudena Santos, Fiona Campbell, Carlos Figueiredo, Lesley Ellies, Ulrike Weyer-Czernilofsky, Thomas Bogenrieder, Michael Schmid, Ainhoa Mielgo. Blockade of insulin-like growth factors increases efficacy of paclitaxel in metastatic breast cancer. Oncogene, 2018. DOI: 10.1038/s41388-017-0115-x
  • Lucy Ireland, Almudena Santos, Muhammad S. Ahmed, Carolyn Rainer, Sebastian R. Nielsen, Valeria Quaranta, Ulrike Weyer-Czernilofsky, Danielle D. Engle, Pedro Perez-Mancera, Sarah E. Coupland, Azzam Taktak, Thomas Bogenrieder , David A. Tuveson , Fiona Campbell , Michael C. Schmid, Ainhoa Mielgo. Chemoresistance in pancreatic cancer is driven by stroma-derived insulin-like growth factors. Cancer Research, 2016. DOI: 10.1158/0008-5472.CAN-16-1201
  • Sebastian Nielsen, Valeria Quaranta, Andrea Linford, Perpetua Emeagi, Carolyn Rainer, Almudena Santos, Lucy Ireland, Takao Sakai, Keiko Sakai, Yong-Sam Kim, Dannielle Engle, Fiona Campbell, Daniel Palmer, Jeong Heon Ko, David Tuveson, Emilio Hirsch, Ainhoa Mielgo, and Michael Schmid. Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis. Nature Cell Biology, 2016. DOI: 10.1038/ncb3340
  • Kaneda MM, Cappello P, Nguyen AV, Ralainirina N, Hardamon CR, Foubert P, Schmid MC, Sun P, Mose E, Bouvet M, Lowy AM, Valasek MA, Sasik R, Novelli F, Hirsch E, Varner JA. Macrophage PI3Kγ drives pancreatic ductal adenocarcinoma progression. Cancer Discovery, 2016. DOI: 10.1158/2159-8290.CD-15-1346
  • Abu-Alainin W, Gana T, Liloglou T, Olayanju A, Barrera LN, Ferguson R, Campbell F, Andrews T, Goldring C, Kitteringham N, Park BK, Nedjadi T, Schmid MC, Slupsky JR, Greenhalf W, Neoptolemos JP, Costello E. UHRF1 regulation of the Keap1-Nrf2 pathway in pancreatic cancer contributes to oncogénesis. J Pathology, 2016. DOI: 10.1002/path.4665
  • Sunil Advani, Maria Fernanda Camargo, Laetitia Seguin, Ainhoa Mielgo, Sudarshan Anand, Angel Hicks, Joseph Aguilera, Aleksandra Franovic, Sara Weis and David Cheresh. Kinase-independent role for CRAF drives tumor radioresistance via CHK2. Nature Communications, 2015. DOI: 10.1038/ncomms9154
  • Laetitia Seguin, Shumei Kato, Aleksandra Franovic, M. Fernanda Camargo, Jacqueline Lesperance, Kathryn C. Elliott, Mayra Yebra, Ainhoa Mielgo, Andrew M. Lowy, Hatim Husain, Tina Cascone, Lixia Diao, Jing Wang, Ignacio I. Wistuba, John V. Heymach, Scott M. Lippman, Jay S. Desgrosellier, Sudarshan Anand, Sara M. Weis, David A. Cheresh. An integrin β3–KRAS–RalB complex drives tumour stemness and resistance to EGFR inhibition. Nature Cell Biology, 2014. DOI: 10.1038/ncb2953
  • Ainhoa Mielgo and Michael C. Schmid. Impact of tumour associated macrophages in pancreatic cancer. BMB Reports, 2013. DOI: 10.5483/bmbrep.2013.46.3.036
  • Garmy-Susini B, Avraamides CJ, Desgrosellier JS, Schmid MC, Foubert P, Ellies LG, Lowy AM, Blair SL, Vandenberg SR, Datnow B, Wang HY, Cheresh DA, Varner J. PI3Kα activates integrin α4β1 to establish a metastatic niche in lymph nodes. Proc Natl Acad Sci U S A. 2013. DOI: 10.1073/pnas.1219603110
  • Schmid MC, Franco I, Kang SW, Hirsch E, Quilliam LA, Varner JA. PI3-Kinase γ promotes Rap1a-mediated activation of myeloid cell integrin α4β1, leading to tumor inflammation and growth. PLoS One, 2013. DOI: 10.1371/journal.pone.0060226
  • Schmid MC and Varner JA. Myeloid cells and tumor inflammation. Vascular Cell, 2012. DOI: 10.1186/2045-824X-4-14
  • Yuan RT, Young S, Liang J, Schmid MC, Mielgo A, Stupack DG. Caspase-8 isoform 6 promotes death effector filament formation independent of microtubules. Apoptosis, 2012. DOI: 10.1007/s10495-011-0677-y
  • Schmid MC, Avraamides CJ, Dippold H, Franco I, Foubert P, Acevedo LM, Ellies LG, Manglicmot J, Wrasidlo W, Blair SL, Ginsberg MH, Cheresh DA, Hirsch E, Field S, and Varner JA. Receptor tyrosine kinases and TLR/IL1R unexpectedly activate myeloid PI3Kg a single convergent point promoting tumor inflammation and progression. Cancer Cell. 2011. DOI: 10.1016/j.ccr.2011.04.016
  • Ainhoa Mielgo, Laetitia Seguin, Miller Huang, Fernanda Camargo, Sudarshan Anand, Aleksandra Franovic, Sara Weis, Sunil Advani, Eric Murphy, David A. Cheresh. A MEK-independent role for CRAF in mitosis and tumor progression. Nature Medicine, 2011. DOI: 10.1038/nm.2464
  • Schmid MC, Avraamides CJ, Foubert P, Saked Y, Kang SW, Kerbel R, and Varner JA. Combined blockade of integrin a4b1 plus cytokines SDF-1a or IL-1b potently inhibits tumor inflammation and growth. Cancer Research, 2011. DOI: 10.1158/0008-5472.CAN-11-0588
  • David J. Shields, Eric Murphy, Jay S. Desgrosellier, Ainhoa Mielgo, Leo Barnes, Jacqueline Lesperance, Christian Schmedt, David Tarin, Andrew M. Lowy and David A. Cheresh. Oncogenic Ras/Src cooperativity in pancreatic neoplasia. Oncogene, 2011. DOI: 10.1038/onc.2010.589
  • Isabelle Tanjoni, Colin Walsh, Sean Uryu, Ainhoa Mielgo, Alok Tomar, Ju-Ock Nam, Chris Liang, Marcel Koenig, Connie Sun, Cheni Kwok, Neela Patel, Gerald McMahon, Dwayne Stupack and David Schlaepfer. PND-1186 PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments. Cancer Biol. Ther., 2010. DOI: 10.4161/cbt.9.10.11434
  • David J. Shields, Sherry Niessen, Eric Murphy, Ainhoa Mielgo, Leo Barnes, Jacqueline Lesperance, David Tarin, Michael Bouvet, Benjamin F. Cravatt, David A. Cheresh. RBBP9: a tumor associated serine hydrolase activity required for pancreatic neoplasia. Proc. Natl. Acad. Sci., 2010. DOI: 10.1073/pnas.0911646107
  • Vicente Torres, Ainhoa Mielgo, Simone Barbero, Ruth Hsiao, John A. Wilkins, Sandra L. Schmid and Dwayne G. Stupack. Rab5 mediates caspase 8 promoted cell motility and metastasis. Mol. Biol. Cell., 2010. DOI: 10.1091/mbc.e09-09-0769
  • Ainhoa Mielgo, Vicente A. Torres, Michael C. Schmid, Simone Barbero, David J. Shields, Samantha G. Zeitlin and Dwayne G. Stupack. The death effector domains of caspase 8 induce terminal differentiation. PLoS ONE, 2009. DOI: 10.1371/journal.pone.0007879
  • Ainhoa Mielgo, Vicente A. Torres, Kiran Clair and Dwayne G. Stupack. Paclitaxel promotes a caspase 8-mediated apoptosis via death effector domain association with microtubules. Oncogene, 2009. DOI: 10.1038/onc.2009.210
  • S Barbero, A Mielgo, L Wu, D Shields, T Teitz, D Mikolon, D Barila, J Lahti, D Schlaepfer and D Stupack. Caspase 8 association with the focal adhesion complex promotes cellular migration and cancer metastasis. Cancer Research, 2009. DOI: 10.1158/0008-5472.CAN-08-3937
  • Vicente A. Torres, Ainhoa Mielgo, Deborah Anderson, Dwayne G. Stupack. Caspase 8 promotes peripheral localization and activation of Rab5. J. Biol. Chem, 2008. DOI: 10.1074/jbc.M805878200
  • Simone Barbero, Daniela Barila, Ainhoa Mielgo, Venturina Stagni, Kiran Clair and Dwayne Stupack. Identification of a critical tyrosine residue in caspase 8 that promotes cell migration. J. Biol. Chem, 2008. DOI: 10.1074/jbc.M805878200
  • Ainhoa Mielgo*, Wolf Wrasidlo*, Vicente A. Torres, Simone Barbero, Konstantin Stoletov, Takashi L. Suyama, Richard L. Klemke, William H. Gerwick, Dennis A. Carson and Dwayne G. Stupack. The marine lipopeptide somocystinamide A triggers apoptosis via caspase 8. Proc. Natl. Acad. Sci, 2008. DOI: 10.1073/pnas.0712198105
  • L Wu, JA Bernard-Trifilo, Y lim, S-T Lim, SK Mitra, S Uryu, M Chen, CJ Pallen, N-KV Cheung, D Mikolon, A Mielgo, DG Stupack and DD Schlaepfer. Distinct FAK-Src activation events promote alpha5beta1 and alpha4beta1 integrin-stimulated neuroblastoma cell motility. Oncogene, 2008. DOI: 10.1038/sj.onc.1210770
  • Peter Erb, Jingmin Ji, Erwin Kump, Ainhoa Mielgo, and Marion Wernli. Apoptosis and pathogenesis of melanoma and non-melanoma skin cancer. Adv. Exp. Med. Biol. 2008. DOI: 10.1007/978-0-387-77574-6_22
  • Ainhoa Mielgo, Vincent Brondani, Lukas Landmann, Andrea Glaser-Rhum, Peter Erb, Dwayne Stupack and Ursula Günthert. The CD44 standard/ezrin complex regulates Fas mediated apoptosis in Jurkat cells. Apoptosis, 2007. DOI: 10.1007/s10495-007-0115-3
  • Ainhoa Mielgo, Marjolein van Driel, AC. Bloem, Lukas Landmann, Ursula Günthert. A novel anti-apoptotic mechanism based on interference of Fas signaling by CD44 variant isoforms. Cell death and differentiation, 2006. DOI: 10.1038/sj.cdd.4401763
  • Ji J, Marion Wernly, Ainhoa Mielgo, Stanislaw A. Buechner, Peter Erb. Fas-ligand gene silencing in basal cell carcinoma tissue with small interfering RNA. Gene Therapy, 2005. DOI: 10.1038/sj.gt.3302453

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